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MPA is actually a powerful agonist in the progesterone receptor with related affinity and efficacy relative to progesterone.[131] Though both MPA and its deacetylated analogue medroxyprogesterone bind to and agonize the PR, MPA has approximately 100-fold higher binding affinity and transactivation potency in comparison.[131] Therefore, unlike MPA, medroxyprogesterone is not used clinically, though it's got found some use in veterinary drugs.